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TMC6 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520505

Catalog No. PIPA520505


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Description

Description

A suggested positive control is human spleen tissue lysate. PA5-20505 can be used with blocking peptide PEP-0625.

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.
Specifications

Specifications

TMC6
Polyclonal
Unconjugated
TMC6
Liquid
TMC6
A 15 amino acid peptide from near the center of human EVER1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q7Z403, Q7TN60
EV1, EVER1, EVIN1, LAK-4P; epidermodysplasia verruciformis 1; epidermodysplasia verruciformis protein 1; expressed in activated T/LAK lymphocytes; protein LAK-4; transmembrane channel-like protein 6
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
11322, 217353
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