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EXOSC7 Mouse anti-Human, Clone: 2F10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA521390

Catalog No. PIMA521390


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Description

Description

Peptide Sequence: LSVENVPCIV TLCKIGYRHV VDATLQEEAC SLASLLVSVT SKGVVTCMRK VGKGSLDPES IFEMMETGKR VGKVLHASLQ SVLHKEESLG PKRQKVGFLG

Non-catalytic component of the RNA exosome complex which has 3 ft.->5 ft. exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding  ft.pervasive ft. transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 ft. untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Specifications

Specifications

EXOSC7
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
Q15024
EXOSC7
EXOSC7 (NP_055819.1, 192 a.a. ∽ 291 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA
2F10
Unconjugated
EXOSC7
Liquid
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
23016
Documents
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