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CRM1 Rabbit anti-Bovine, Canine, Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141634

Catalog No. 01-675-247


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Description

Description

PA1-41634 detects Exportin-1 in chimpanzee, bovine, canine and human samples. This antibody is predicted to cross react with mouse and rat samples based on sequence homology. Suggested positive control: Jurkat whole cell lysate.

Nuclear transport receptors of karyopherin/importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-1, a human homolog of yeast CRM1, is a novel karyopherin export receptor that mediates leucine-rich NES-dependent protein export. It interacts with RanGTP through its Ran-binding domain and also with nucleoporins including Nup214, Nup50, Nup42 and Nup159 during the process of exporting NES-containing proteins.  It mediates the export of many cellular and viral proteins and ribonucleoproteins including HIV Rev Protein, ERK3, PKI, IRF-5, Cyclin-B, MAPKK, MAPKAP kinase 2, Snurportin, Cap-binding protein, and certain U snRNAs. Reports suggest exportin-1 also has a role in the regulation of NFAT and AP-1.
Specifications

Specifications

CRM1
Polyclonal
Unconjugated
XPO1
Liquid
XPO1
Synthetic peptide corresponding to residues A(390) S P L L S G S Q H F D V P P R R Q L(408) of human Exportin-1.
Protein G
RUO
Antibody
Polyclonal
Bovine, Canine, Human, Non-human Primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
O14980
XPO1, CRM1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
474609, 510568, 7514
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