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FBXW7 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA123468

Catalog No. PIPA123468


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Description

Description

PA1-23468 detects F-box hCdc4 in Human samples. PA1-23468 has been successfully used in ELISA and Western Blot procedures. PA1-23468 immunogen corresponds to Rabbit Polyclonal to F - box hCdc4 (69 kDa isoform) Protein. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.
Specifications

Specifications

FBXW7
Polyclonal
Unconjugated
FBXW7
Liquid
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
55294
ELISA, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q969H0
FBXW7
Rabbit Polyclonal to F - box hCdc4 (69 kDa isoform) Protein
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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