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FBXW7 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14253

Catalog No. PA14253


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Description

Description

PA1-4253 detects the F-box hCdc4 (69 kDa isoform) protein in human samples. PA1-4253 has been successfully used in Western blot procedures. PA1-4253 immunizing peptide corresponds to the N terminus of the 69 kDa isoform of the hCdc4 protein. Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid freeze/thaw cycles.

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.
Specifications

Specifications

FBXW7
Polyclonal
Unconjugated
FBXW7
Liquid
FBXW7
Synthetic peptide corresponding to the N-terminus of the 69 kDa isoform of the hCdc4 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q969H0
AGO, CDC4, DKFZp686F23254, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ16457, SEL-10, SEL10
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
55294
Documents
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