FBXW7 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14253
PA1-4253 detects the F-box hCdc4 (69 kDa isoform) protein in human samples. PA1-4253 has been successfully used in Western blot procedures. PA1-4253 immunizing peptide corresponds to the N terminus of the 69 kDa isoform of the hCdc4 protein. Maintain at 4°C for 3 months or at -20°C for longer periods. Avoid freeze/thaw cycles.Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is critical for the initiation of DNA replication and other S-phase functions. The proper timing and amplitude of cyclin E expression seem to be important, because elevated levels of cyclin E have been associated with a variety of maligcies and constitutive expression of cyclin E leads to genomic instability. Phosphorylated cyclin E depends on the novel human gene, hCdc4, that was found to be mutated in a cell line derived from breast cancer that expressed extremely high levels of cyclin E.
|Synthetic peptide corresponding to the N-terminus of the 69 kDa isoform of the hCdc4 protein.|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|AGO, CDC4, DKFZp686F23254, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ16457, SEL-10, SEL10|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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