Factor XII Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526672
DescriptionThis gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.
|KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human F12|
|Antigen affinity chromatography|
|PBS with 0.09% sodium azide|
|HAE3, HAEX, HAF, Hageman factor, beta-factor XIIa part 1, beta-factor XIIa part 2, coagulation factor XII, coagulation factor XIIa heavy chain, coagulation factor XIIa light chain|
|-20° C, Avoid Freeze/Thaw Cycles|
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