Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Our pricing system is unavailable. You are viewing list price.
Please call 1-800-766-7000 to place your order or try our site again later.

Factor XII Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA526672

Catalog No. PIPA526672



Description

Description

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.
Specifications

Specifications

Factor XII
Polyclonal
Unconjugated
F12
Liquid
F12
KLH conjugated synthetic peptide between 7-34 amino acids from the N-terminal region of human F12
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
P00748
HAE3, HAEX, HAF, Hageman factor, beta-factor XIIa part 1, beta-factor XIIa part 2, coagulation factor XII, coagulation factor XIIa heavy chain, coagulation factor XIIa light chain
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2161
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit