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Complement Factor B Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527924

Catalog No. PIPA527924


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Description

Description

PA5-27924 targets Factor B in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27924 immunogen is recombit fragment corresponding to a region within amino acids 188 and 551 of Human Factor B. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5 ft. end of the gene for complement component 2.
Specifications

Specifications

Complement Factor B
Polyclonal
Unconjugated
CFB
Liquid
CFB
Recombit fragment corresponding to a region within amino acids 188 and 551 of Human Factor B
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry (Paraffin), Western Blot
0.87 mg/mL
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
P00751
AHUS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2, B-factor, properdin, C3 proaccelerator, C3 proactivator, C3/C5 convertase, glycine-rich beta glycoprotein, glycine-rich beta-glycoprotein, properdin factor B
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
294257, 629
Documents
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