Factor VII Rat anti-Mouse, Clone: 9031, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA143038
MA1-43038 detects Factor VII in mouse samples. MA1-43038 has successfully been used in Western blot and ELISA applications. MA1-43038 was derived from mouse factor VII.Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
|Mouse Factor VII.|
|Ammonium sulfate precipitation, Ion-exchange chromatography|
|ELISA, Western Blot|
|50%water with 50% glycerol and no preservative|
|F7, Coagulation factor 7|
|-20° C, Avoid Freeze/Thaw Cycles|
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