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Factor VIII Mouse anti-Human, Clone: F8C-27.4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110590

Catalog No. 01-671-544



Description

Description

MA1-10590 recognizes an epitope in the N-terminal region of the 83kDa light chain of human Factor VIII. This antibody does not cross-react with von Willebrand factor. MA1-10590 has been successfully used in ELISA and Western blot applications. The MA1-10590 immunogen is purified human Factor VIII.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Specifications

Specifications

Factor VIII
Monoclonal
1.0 mg/mL
PBS with no preservative; pH 7.4
P00451
RP11-115M6.7, AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Mouse
IgG2a
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2157
ELISA, Western Blot
F8C-27.4
Unconjugated
F8
Liquid
F8
Purified human Factor VIII.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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