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Factor VIII Rat anti-Mouse, Clone: 9035, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA143037

Catalog No. 01-676-483


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Description

Description

MA1-43037 detects Factor VIII in mouse samples. MA1-43037 has successfully been used in Western blot and ELISA applications. MA1-43037 was derived from mouse factor VIII.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Specifications

Specifications

Factor VIII
Monoclonal
8.1 mg/mL
50%water with 50% glycerol and no preservative
Q06194
F8, HEMA, AHF, Coagulation factor 8
Rat
Ammonium sulfate precipitation, Ion-exchange chromatography
RUO
Antibody
Monoclonal
Mouse
ELISA, Western Blot
9035
Unconjugated
F8
Liquid
F8
Mouse Factor VIII.
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14069
Documents
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