Factor VIII Sheep anti-Human, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA143045
PA1-43045 detects Factor VIII in human samples. PA1-43045 has successfully been used in Western blot and ELISA applications. PA1-43045 was derived from human factor VIII. The molecular weight of PA1-43045 is 150 kDa.This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
|Human Factor VIII.|
|Ammonium sulfate precipitation, Ion-exchange chromatography|
|ELISA, Western Blot|
|50%water with 50% glycerol and no preservative|
|F8, HEMA, AHF, Coagulation factor 8|
|-20° C, Avoid Freeze/Thaw Cycles|
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