Factor X Sheep anti-Human, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA143047
PA1-43047 detects Factor X in human samples. PA1-43047 has successfully been used in Western blot and ELISA applications. PA1-43047 was derived from human factor X.F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
|Human Factor X.|
|Ammonium sulfate precipitation, Ion-exchange chromatography|
|ELISA, Western Blot|
|50%water with 50% glycerol and no preservative|
|F10, Coagulation factor 10, Stuart factor|
|-20° C, Avoid Freeze/Thaw Cycles|
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