Factor XI Sheep anti-Human, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA143048
PA1-43048 detects Factor XI in human samples. PA1-43048 has successfully been used in Western blot and ELISA applications. PA1-43048 was derived from human factor XI.Factor XI is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
|Human Factor XI.|
|Ammonium sulfate precipitation, Ion-exchange chromatography|
|ELISA, Western Blot|
|50%water with 50% glycerol and no preservative|
|F11, Coagulation factor 11|
|-20° C, Avoid Freeze/Thaw Cycles|
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