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Factor XI Sheep anti-Human, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA143048

Catalog No. PA143048


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Description

Description

PA1-43048 detects Factor XI in human samples. PA1-43048 has successfully been used in Western blot and ELISA applications. PA1-43048 was derived from human factor XI.

Factor XI is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Specifications

Specifications

Factor XI
Polyclonal
Unconjugated
F11
Liquid
F11
Human Factor XI.
Ammonium sulfate precipitation, Ion-exchange chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Western Blot
12.4 mg/mL
50%water with 50% glycerol and no preservative
P03951
F11, Coagulation factor 11
Sheep
IgG
1 mg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2160
Documents
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