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Factor XII Heavy chain Mouse anti-Human, Clone: B7C9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110828

Catalog No. 01-671-856


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Description

Description

MA1-10828 detects Factor XII heavy chain, from human samples. MA1-10828 has been successfully used in ELISA and Western blot applications. By Western blot, this antibody detects a ~50 kDa band representing the non-reduced heavy chain of Factor XII from normal human plasma . The MA1-10828 immunogen is purified human Factor XII.

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Specifications

Specifications

Factor XII Heavy chain
Monoclonal
1.4 mg/mL
PBS with no preservative; pH 7.4
P00748
HAE3, HAEX, HAF
Mouse
IgG1
250 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2161
ELISA, Western Blot
B7C9
Unconjugated
F12
Liquid
F12
Purified human Factor XII.
Protein G
RUO
Antibody
Monoclonal
Human
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