Factor XII Sheep anti-Human, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA143049
PA1-43049 detects Factor XII in human samples. PA1-43049 has successfully been used in Western blot and ELISA applications. PA1-43049 was derived from human factor XII.This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
|Human Factor XII.|
|Ammonium sulfate precipitation, Ion-exchange chromatography|
|ELISA, Western Blot|
|50%water with 50% glycerol and no preservative|
|F12, Coagulation factor 12|
|-20° C, Avoid Freeze/Thaw Cycles|
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