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Factor XIII Sheep anti-Human, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA143050

Catalog No. PA143050


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Description

Description

PA1-43050 detects Factor XIII in human samples. PA1-43050 has successfully been used in Western blot and ELISA applications. PA1-43050 was derived from human factor XIII.

Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Specifications

Specifications

Factor XIII
Polyclonal
50%water with 50% glycerol and no preservative
P00488
Coagulation factor 13
Sheep
IgG
1 mg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2162
ELISA, Western Blot
Unconjugated
F13A1
Liquid
F13A1
Human Factor XIII.
Ammonium sulfate precipitation, Ion-exchange chromatography
RUO
Antibody
Polyclonal
Human
Documents
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