FAF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520314
A suggested positive control is Jurkat cell lysate. PA5-20314 can be used with blocking peptide PEP-0434.Fas-associated protein 1 (FAF1) was initially identified as a Fas-binding pro-apoptotic protein that is component of the death-inducing signaling complex in Fas-mediated apoptosis. FAF1 can also induce apoptosis in the absence of extrinsic death signals when overexpressed although it does not contain typical death motifs such as the death domain, death effector domain, and caspase recruitment domain. Overexpression of FAF1 also decreases the basal level of NF-kappa-B activity in transfected 293 cells, inhibits NF-kappa-B activity induced by TNF-a, IL-1-b and lipopolysaccharide, and prevents NF-kappa-B translocation to the nucleus, suggesting that another role of FAF1 is to negatively regulate the activity of NF-kappa-B. FAF1 can also interact with the inflammatory signaling PYRIN-containing Apaf-1-like proteins (PYPAFs, also called NALPs) such as PYPAF1, PYPAF2 (NALP2), and PYPAF7, suggesting FAF1 may also be involved in the inflammation pathway. Multiple differentially spliced isoforms of FAF1 are known to exist.
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|11124, 140657, 14084|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9UNN5, P54731, Q924K2|
|A 19 amino acid peptide from near the carboxy terminus of human FAF1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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