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FAK Mouse, Unlabeled, Clone: 77/FAK, BD

Mouse Monoclonal Antibody

$226.00 - $448.00

Specifications

Antigen FAK
Isotype IgG1
Immunogen Chicken FAK aa. 354-533
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610087
View Documents Promotion Details
BD Biosciences
610087
50μg
Each for $226.00
Add to cart
 
BDB610088
View Documents Promotion Details
BD Biosciences
610088
150μg
Each for $448.00
Add to cart
 
Description

Description

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting sequence” (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation and activation of FAK. This creates binding sites for SH2 domains of intracellular signaling molecules such as src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions has led to substantial speculation about its function. Although FAK's precise role has not been elucidated, proposed possibilities include regulating cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 77
Isotype: IgG1
Species Reactivity: Human
Immunogen: Chicken FAK aa. 354-533
Formula Weight [Chemical]: 116-125kDa

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

FAK
Chicken FAK aa. 354-533
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Focal Adhesion Kinase
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
77/FAK
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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