FAM120A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520800
A suggested positive control is SK-N-SH cell lysate. PA5-20800 can be used with blocking peptide PEP-0914.FAM120A (C9orf10) is a member of the constitutive coactivator of PPAR -gamma family and the gene was mapped to chromosome 9q22.31. FAM120A was recently detected within the Pur-alpha-containing mRNA-protein complex in the brain. As a novel RNA-binding protein, FAM120A is a critical component of the oxidative stress-induced survival signaling. It may participate in mRNA transport in the cytoplasm. FAM120A activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. FAM120A protects cells from apoptosis through activation of SRKs in response to oxidative stress. Blocking of the survival signaling mediated by FAM120A, which sensitizes the cancer cells to stress-induced apoptosis, may be a novel therapeutic approach for gastric scirrhous carcinoma cells.
|An 18 amino acid peptide from near the center of human FAM120A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|C9orf10, DNAPTP1, DNAPTP5, OSSA; DNA polymerase-transactivated protein 1; DNA polymerase-transactivated protein 5; constitutive coactivator of PPAR-gamma-like protein 1; oxidative stress-associated Src activator|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|218236, 23196, 291019|
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