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FANCD2 Rabbit anti-Human, Mouse, Non-human primate, HRP, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522707

Catalog No. PIPA522707


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Description

Description

In Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form). Additional bands may be seen at lower molecular weights.

FANCD2 (Fanconi anemia group D2 protein) is required for maintece of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
Specifications

Specifications

FANCD2
Polyclonal
HRP
FANCD2
Liquid
FANCD2
Human FANCD2 fusion protein (N-terminal fragment).
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
1.28 mg/mL
PBS with no preservative
Q9BXW9, Q80V62
FA-D2, FA4, FACD, FAD, FAD2, FANCD, Fanconi anemia group D2 protein
Rabbit
IgG
50 μL
4° C, store in dark
Primary
211651, 2177
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