MilliporeSigma anti-Fas (Ab-1) (321-335), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC69100UG
Specifically detects Fas (321-335) Clone: in Human, Mouse, Opossum, Rat samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno BlottingFas/APO-1 was originally described as a cell surface antigen on activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. The gene encoding the human fas antigen consists of 9 exons, spans more than 26 kb of DNA and shares 58.5% homology with the mouse homolog. The protein contains a single transmembrane domain which is rich in cysteine residues and an inhibitory as well as a signal transducing or death domain in the cytoplasmic domain. Ligation or crosslinking of the extracellular domain by fas ligand or by antibody elicits a characteristic apoptotic response in susceptible cells including lymphoid cells and tumors as well as non-hematopoietic tumors. Upon activation, fas associates with a number of other proteins to mediate the response. Fas is a member of the TNF receptor family and shares some sequence homology with the TNF receptor but does not appear to physically interact with TNF-R itself.
|a synthetic peptide (DSENSNFRNEIQSLV) corresponding to amino acids 321-335 of human Fas|
|2°C to 8°C|
|Human, Murine, Opossum, Rat|
|Immuno Blotting, Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|In 0.05M sodium phosphate buffer, 0.2% gelatin.|
|Recognizes the ∽44-46kDa Fas protein in HL60 cells and color tissue.|
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