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MilliporeSigma™ anti-Fas (Ab-1) (321-335), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC69100UG

Catalog No. PC69100UG


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Description

Description

Specifically detects Fas (321-335) Clone: in Human, Mouse, Opossum, Rat samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno Blotting

Fas/APO-1 was originally described as a cell surface antigen on activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. The gene encoding the human fas antigen consists of 9 exons, spans more than 26 kb of DNA and shares 58.5% homology with the mouse homolog. The protein contains a single transmembrane domain which is rich in cysteine residues and an inhibitory as well as a signal transducing or death domain in the cytoplasmic domain. Ligation or crosslinking of the extracellular domain by fas ligand or by antibody elicits a characteristic apoptotic response in susceptible cells including lymphoid cells and tumors as well as non-hematopoietic tumors. Upon activation, fas associates with a number of other proteins to mediate the response. Fas is a member of the TNF receptor family and shares some sequence homology with the TNF receptor but does not appear to physically interact with TNF-R itself.
Specifications

Specifications

Fas (321-335)
Unconjugated
purified
a synthetic peptide (DSENSNFRNEIQSLV) corresponding to amino acids 321-335 of human Fas
100μg
2°C to 8°C
Polyclonal
Human, Murine, Opossum, Rat
Immuno Blotting, Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Rabbit
IgG
RUO
Primary
Recognizes the ∽44-46kDa Fas protein in HL60 cells and color tissue.
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