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FDPS Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528228

Catalog No. PIPA528228


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Description

Description

The PA5-28228 immunogen is recombit fragment corresponding to a region within amino acids 43 and 381 of Human FDPS. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

FDPS
Polyclonal
Unconjugated
FDPS
Liquid
FDPS
Recombit fragment corresponding to a region within amino acids 43 and 381 of Human FDPS
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1.88 mg/mL
PBS with 20% glycerol and 0.025% Proclin 300; pH 7
P14324, Q920E5
FPPS, FPS, (2E,6E)-farnesyl diphosphate synthase, FPP synthase, FPP synthetase, dimethylallyltranstransferase, farnesyl pyrophosphate synthase, farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase, geranyltranstransferase
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
110196, 2224
Documents
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