FEN-1 Mouse, Unlabeled, Clone: 21, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611294
The fidelity of DNA replication, recombination, and repair is essential for genome stability. Proteins that have exonuclease and endonuclease enzymatic activity are critical for accurate replication, recombination, and repair of DNA sequences. FEN-1 ( 5 ft. exonuclease-1 or flap endonuclease-1) is an exo- and endonuclease found in yeast, mouse, and human. The 5 ft.-3 ft. exonuclease activity of FEN-1 involves only double stranded DNA and is important for processing Okazaki fragments during lagging strand DNA synthesis. In addition, FEN-1 is a member of the RAD2 family of repair nucleases and may participate in DNA repair. Its endonuclease activity is specific for 5 ft. overhanging flaps, which are
intermediates in the repair of DNA double strand breaks. Human and mouse FEN-1 are highly conserved with 95% identity at the amino acid level. FEN-1 expression is highest during entry into the mitotic cell cycle and lowest in differentiated cells. Thus, FEN-1 is an exo- and endonuclease that is thought to be essential for maintaining DNA integrity during replication, as well as after damage by alkylating agents or UV.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human FEN-1 aa. 252-371
Formula Weight [Chemical]: 50kDa
Bioimaging, Immunofluorescence, Western Blotting
|Canine, Human, Murine, Rat|
|Immunofluorescence, In vitro Assay, Western Blot|
|Human FEN-1 aa. 252-371|
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