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FEN-1 Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611294

Catalog No. BDB611294

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

The fidelity of DNA replication, recombination, and repair is essential for genome stability. Proteins that have exonuclease and endonuclease enzymatic activity are critical for accurate replication, recombination, and repair of DNA sequences. FEN-1 ( 5 ft. exonuclease-1 or flap endonuclease-1) is an exo- and endonuclease found in yeast, mouse, and human. The 5 ft.-3 ft. exonuclease activity of FEN-1 involves only double stranded DNA and is important for processing Okazaki fragments during lagging strand DNA synthesis. In addition, FEN-1 is a member of the RAD2 family of repair nucleases and may participate in DNA repair. Its endonuclease activity is specific for 5 ft. overhanging flaps, which are
intermediates in the repair of DNA double strand breaks. Human and mouse FEN-1 are highly conserved with 95% identity at the amino acid level. FEN-1 expression is highest during entry into the mitotic cell cycle and lowest in differentiated cells. Thus, FEN-1 is an exo- and endonuclease that is thought to be essential for maintaining DNA integrity during replication, as well as after damage by alkylating agents or UV.

Host Species: Mouse
Clone: 21
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human FEN-1 aa. 252-371
Formula Weight [Chemical]: 50kDa

Bioimaging, Immunofluorescence, Western Blotting

Specifications

Specifications

FEN-1
21
Unconjugated
Murine
IgG1
RUO
Primary
Canine, Human, Murine, Rat
Immunofluorescence, In vitro Assay, Western Blot
250μg/mL
Affinity Purified
Human FEN-1 aa. 252-371
50μg
Cell Biology
Monoclonal
Documents
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