FEN1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA512480
This antibody is predicted to react with bovine based on sequence homology.FEN1 removes 5 ft. overhanging flaps in DNA repair and processes the 5 ft. ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. This protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 ft. end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
|PBS with 0.09% sodium azide|
|Flap endonuclease 1; Flap structure-specific endonuclease 1; Maturation factor 1; DNase IV; RAD2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|KLH conjugated synthetic peptide between 243-272 amino acids from the central region of human FEN1|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
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