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FEN1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512480

Catalog No. PIPA512480

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine based on sequence homology.

FEN1 removes 5 ft. overhanging flaps in DNA repair and processes the 5 ft. ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. This protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 ft. end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Specifications

Specifications

FEN1
Polyclonal
PBS with 0.09% sodium azide
P39748
Flap endonuclease 1; Flap structure-specific endonuclease 1; Maturation factor 1; DNase IV; RAD2
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2237
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
FEN1
Liquid
FEN1
KLH conjugated synthetic peptide between 243-272 amino acids from the central region of human FEN1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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