FEZ1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520396
Despite its predicted molecular weight, FEZ1 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is SK-N-SH cell lysate. PA5-20396 can be used with blocking peptide PEP-0513.Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.
|A 19 amino acid peptide from near the carboxy terminus of human FEZ1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|Q99689, Q8K0X8, P97577|
|fasciculation and elongation protein zeta-1; zygin I; zygin-1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|235180, 81730, 9638|
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