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FGF2 Sheep anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA118362

Catalog No. 01-670-614


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Description

Description

PA1-18362 detects Basic FGF from human, mouse, and rat samples. PA1-18362 has been successfully used in immunohistochemistry procedures. The PA1-18362 immunogen is recombit human basic FGF. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Reconstitute with 100 µL of distilled water. Glycerol (1:1) may be added for additional stability.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predomitly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
Specifications

Specifications

FGF2
Polyclonal
Unconjugated
FGF2
Lyophilized
FGF2
Recombit human basic FGF.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry
1 mg/mL
Antibody with no preservative
P09038, P15655, P13109
Heparin-binding growth factor 2, HBGF-2, Basic fibroblast growth factor, bFGF, Prostatropin, FGF2, FGFB
Sheep
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14173, 2247, 54250
Documents
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