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FGF4 Rat anti-Mouse, Clone: 678430, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524307

Catalog No. PIMA524307


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Description

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
Specifications

Specifications

FGF4
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P11403
HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF, FGF-4, HSTF-1, fibroblast growth factor 4 splice isoform, heparin secretory transforming protein 1, heparin secretory-transforming protein 1, heparin-binding growth factor 4, human stomach cancer, transforming factor from FGF-related oncogene, kaposi sarcoma oncogene, oncogene HST, transforming protein KS3
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14175
Western Blot
678430
Unconjugated
Fgf4
Lyophilized
FGF4
E. coli-derived recombit mouse FGF-4 Ala30-Leu202
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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