FGFR3 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA514655

Catalog No. PIPA514655

Description

FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintece. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Specifications

• Antigen: FGFR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Accession No.: P22607
• Gene Symbols: FGFR3
• Immunogen: KLH conjugated synthetic peptide between 776-806 amino acids from the C-terminal region of human FGFR3
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2 mg/mL
• Gene: FGFR3
• Gene Alias: Fibroblast Growth Factor Receptor 3, ACH, CEK2, HSFGFR3EX, JTK4, FGFR-3, fibroblast growth factor receptor 3 variant 4, hydroxyaryl-protein kinase, tyrosine kinase JTK4, FGF Receptor 3
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 2261
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid