FHIT Mouse, Unlabeled, Clone: 30, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611740
Multiple tumor-derived cell lines have homozygous deletions in a 200-300kb region in chromsome 3p14.2. This region includes the fragile site locus FRA3B, which may contain deletions in tumor suppressor genes. Abnormalities in the expression and structure of a gene, FHIT, that spans the FRA3B locus have been observed in a variety of carcinomas. FHIT (Fragile Histidine Triad) is widely expressed in normal embryonic and adult tissues and is absent in lung, renal, and gastric tumors. Exposure of FHIT heterozygous knock-out mice to carcinogens produces increased tumorigenicity similar to that observed in Muir-Torre familial cancer syndrome. The only known function of FHIT is as a diadenosine 5′,5′-P1, P3 triphosphate (Ap3A) hydrolase. Both in vitro and in vivo, FHIT regulates the level of Ap3A and adenosine (57′) tetraphosphate(5′) nucleoside. However, this hydrolase activity may not be involved in FHIT tumor suppressor activity, since a mutant FHIT that binds but does not hydrolyze Ap3A is as effective as the wild-type in reducing tumorigenicity in mouse cancer models. Thus, FHIT activity may be essential for a unique antiproliferative signaling pathway.
Host Species: Mouse
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse FHIT aa. 26-148
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Mouse FHIT aa. 26-148|
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