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ANGPTL4 Rabbit anti-Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA11053

Catalog No. PA11053

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PA1-1053 detects fasting-induced adipose factor (FIAF) from rat and mouse adipose tissue. PA1-1053 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing FIAF from rat adipose tissue extracts. The PA1-1053 immunogen is a synthetic peptide corresponding to residues C(80) Q G P K G K D A P F K D S E(94) of mouse FIAF. PA1-1053 can be used with blocking peptide PEP-178.

Adipose tissue is an energy reserve in animals and, in nondomestic species, is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and Acrp30. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor alpha (PPAR alpha). PPAR alpha has recently been reported to target a novel gene encoding the secreted protein FIAF (fasting-induced adipose factor). FIAF is expressed predomitly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that FIAF represents a novel endocrine signal helping to regulate metabolism, especially under fasting conditions.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly



Synthetic peptide corresponding to residues C(80) Q G P K G K D A P F K D S E(94) of mouse FIAF.
Antigen affinity chromatography
Mouse, Rat
Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q9Z1P8, Q6TMA8
Fasting-Induced Adipose Factor, Angiopoietin-related protein 4, Angiopoietin-like 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP, Fasting-i
100 μg
-20° C, Avoid Freeze/Thaw Cycles
362850, 57875
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