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Fibrinogen Sheep anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA185429

Catalog No. PA185429


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Description

Description

Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex approximately 340 kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of α, beta and γ chains linked by a series of 29 disulphide bonds (Henschen et al. 1983).

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
Specifications

Specifications

Fibrinogen
Polyclonal
Unconjugated
FGB
Liquid
Sheep
IgG
1 mL
4°C or -20°C if preferred
Primary
110135, 14161, 2243, 2244, 2266, 24366, 24367, 361969, 99571
ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
5 mg/mL
PBS with 0.09% sodium azide; pH 7.4
P02671, P02675, P02679, E9PV24, Q8K0E8, Q8VCM7, P02680, P06399, P14480
FGA, FGB, FGG
Human fibrinogen purified from plasma.
Ion-exchange chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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