Fibrinogen Sheep anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA185429
Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex approximately 340 kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of α, beta and γ chains linked by a series of 29 disulphide bonds (Henschen et al. 1983).The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
|4°C or -20°C if preferred|
|110135, 14161, 2243, 2244, 2266, 24366, 24367, 361969, 99571|
|ELISA, Immunofluorescence, Immunohistochemistry (Frozen)|
|PBS with 0.09% sodium azide; pH 7.4|
|P02671, P02675, P02679, E9PV24, Q8K0E8, Q8VCM7, P02680, P06399, P14480|
|FGA, FGB, FGG|
|Human fibrinogen purified from plasma.|
|Human, Mouse, Rat|
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