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FGFR2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA124763

Catalog No. PA124763


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Description

Description

PA1-24763 detects overexpressed FGFR2 from transfected human samples. This antibody shows no cross reactivity with FGFR1 or FGFR3. PA1-24763 is expected to cross react with mouse (92% conserved) and rat (92% conserved) due to sequence homology. PA1-24763 has been successfully used in Immunohistochemistry, immunoprecipitation, and Western blot procedures. The PA1-24763 immunogen is a synthetic peptide, conjugated to KLH by a Glutaraldehyde linker, corresponding to residues K(809) L P Q Y P H I G S V K T(821) of the cytoplasmic region of human FGFR2. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

FGFR2 is a member of the fibroblast growth factor receptor family. It is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a central role in the regulation of cell proliferation, differentiation, migration, apoptosis, and embryonic development. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Specifications

Specifications

FGFR2
Polyclonal
Unconjugated
FGFR2
Liquid
FGFR2
Synthetic peptide, conjugated to KLH by a Glutaraldehyde linker, corresponding to residues K(809) L P Q Y P H I G S V K T(821) of the cytoplasmic region of Human FGFR2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry, Western Blot
1.0 mg/mL
0.01M PBS with 1% BSA and 15mM sodium azide; pH 7.4
P21802, P21803
Fibroblast Growth Factor Receptor 2, BEK, BFR-1, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, CD332, FGF Receptor 2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
14183, 2263
Documents
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