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FGFR4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA131991

Catalog No. PA131991

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

PA1-31991 detects FGFR4 from human samples. PA1-31991 has been successfully used in immunohistochemistry (frozen tissue), immunohistochemistry (paraffin tissue), Western blot and ELISA applications. Detects a band of ~96 kDa. A suggested positive control for this product is THP-1 cell lysate. The PA1-31991 immunogen is a synthetic peptide conjugated to KLH, corresponding to amino acids 39-56 of Human FGFR 4. Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20° C or below, avoiding multiple freeze-thaw cycles.

FGFR4 (Fibroblast Growth Factor Receptor 4), is a member of the FGFR family of receptor tyrosine kinases. This family regulates a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR4 protein is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation, migration, and in the regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism, and phosphate homeostasis. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
Specifications

Specifications

FGFR4
Polyclonal
Unconjugated
FGFR4
Liquid
FGFR4
Synthetic peptide conjugated to KLH, corresponding to amino acids 39-56 of Human FGFR 4.
Protein G
RUO
Antibody
Polyclonal
Human
ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
P22455
Fibroblast Growth Factor Receptor 4, TKF, JTK2, MGC20292, Fibroblast growth factor receptor 4, FGF Receptor 4
Rabbit
IgG
400 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
2264
Documents
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