Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Fibronectin Mouse anti-Human, Mouse, Clone: EP5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112597

Catalog No. 01-674-365


Add to cart

Description

Description

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
Specifications

Specifications

Fibronectin
Monoclonal
1 mg/mL
PBS with 0.08% sodium azide
P02751, P11276
FN, FN1, CIG, Cold insoluble globulin, fibronectin 1, LETS, MSF, Transformation sensitive protein
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14268, 2335
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
EP5
Unconjugated
FN1
Liquid
FN1
T-cell lymphoma biopsy
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit