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Fibronectin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA123693

Catalog No. PA123693


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Description

Description

PA1-23693 detects fibronectin in human samples. This antibody does not cross-react with Fibrinogen or other serum proteins. PA1-23693 has been successfully used in immunohistochemistry (frozen & FFPE) procedures. Prolonged fixation in buffered formalin may destroy the epitope. Auto/Zyme predigestion is recommended when using this antibody with formalin-fixed paraffin-embedded tissue sections. Suggested possitive controls for this product are human tonsil, liver, skin or kidney. The PA1-23693 immunogen is highly purified, human fibronectin.

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
Specifications

Specifications

Fibronectin
Polyclonal
Unconjugated
FN1
Liquid
FN1
Highly purified, human fibronectin from plasma.
Protein A
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
1 mg/mL
PBS with 1% BSA and 0.05% sodium azide; pH 7.4
P02751
FN, FN1, CIG, Cold insoluble globulin, fibronectin 1, LETS, MSF, Transformation sensitive protein
Rabbit
IgG
500 μL
4° C, do not freeze
Primary
2335
Documents
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