Fibulin 3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520761
A suggested positive control is Hela cell lysate. PA5-20761 can be used with blocking peptide PEP-0875.Fibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.
|A 19 amino acid peptide near the carboxy terminus of human Fibulin 3.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|DHRD, DRAD, FBLN3, FBNL, MLVT, MTLV, S1-5; EGF-containing fibulin-like extracellular matrix protein 1; FIBL-3; extracellular protein S1-5; fibulin-3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|216616, 2202, 305604|
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