Fibulin 5 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528843
PA5-28843 targets Fibulin 5 in WB applications and shows reactivity with Human samples. The PA5-28843 immunogen is synthetic peptide corresponding to a region within amino acids 384 and 448 of Human Fibulin 5. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal domit cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
|Synthetic peptide corresponding to a region within amino acids 384 and 448 of Human Fibulin 5|
|Antigen affinity chromatography|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, developmental arteries and neural crest EGF-like protein, fibulin-5, urine p50 protein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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