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FKBP15 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520730

Catalog No. PIPA520730


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Description

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20730 can be used with blocking peptide PEP-0844.

FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.
Specifications

Specifications

FKBP15
Polyclonal
Unconjugated
FKBP15
Liquid
FKBP15
A 15 amino acid peptide from near the amino terminus of human FKBP15.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q5T1M5, Q6P9Q6
FKBP133, KIAA0674, PPP1R76; 133 kDa FK506-binding protein; 133 kDa FKBP; FK506-binding protein 133kDa; FK506-binding protein 15; FKBP-133; FKBP-15; WAFL; protein phosphatase 1, regulatory subunit 76
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
23307, 338355, 362528
Documents
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