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FKBP4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514278

Catalog No. PIPA514278

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.
Specifications

Specifications

FKBP4
Polyclonal
PBS with 0.09% sodium azide
Q02790
FKBP51; FKBP59; HBI; Hsp56; PPIase; p52; 51 kDa FK506-binding protein; 59 kDa FK506-binding protein 4; HSP binding immunophilin; T-cell FK506-binding protein; peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; rotamase
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2288
Flow Cytometry, Western Blot
Unconjugated
FKBP4
Liquid
FKBP4
KLH conjugated synthetic peptide between 186-216 amino acids from the central region of human FKBP4
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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