FKBP4 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA514278
DescriptionFKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.
|PBS with 0.09% sodium azide|
|FKBP51; FKBP59; HBI; Hsp56; PPIase; p52; 51 kDa FK506-binding protein; 59 kDa FK506-binding protein 4; HSP binding immunophilin; T-cell FK506-binding protein; peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; rotamase|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|KLH conjugated synthetic peptide between 186-216 amino acids from the central region of human FKBP4|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
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