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FKBP51 Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610582

Catalog No. BDB610582


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Description

Description

FK506, one of several potent compounds that block T cell proliferation, is used in immunosuppressive therapy. Several FK506-binding proteins (FKBPs) have been identified in the search for intracellular targets of FK506. These proteins include FKBP12, FKBP12.6, and FKBP52. The immunosuppressive effects of FK506and FKBPs result from the inhibition of the calcineurin phosphatase, a well known component of the signaling cascade leading to IL-2 production. Calcineurin and FKBP's are widely distributed, therefore, it is difficult to achieve immunosuppressive specificity by FK506. FKBP51 (51kDa) is an FK506-binding protein that is expressed exclusively in T cells and has homology to FKBP52. Because of its limited distribution, FKBP51 may provide a more selective target for FK506 in T cells.

Specifications

Specifications

FKBP51
18
Unconjugated
Affinity Purified
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
50μg
Cell Biology
Primary
Chicken, Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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