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FLASH Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14167

Catalog No. PA14167

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PA1-4167 detects the FLASH protein in Human, rat, and mouse samples. PA1-4167 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~212 kDa protein representing FLASH in NIH3T3 cells. The PA1-4167 immunogen is a synthetic peptide corresponding to residues A(19) S P L K N N D E G S L D(31) of mouse FLASH. Maintain at 4°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze/thaw cycles.

Fas is a cell-surface receptor molecule that relays apoptotic (cell death) signals into cells. When Fas is activated by binding of its ligand, the proteolytic protein caspase-8 is recruited to a signalling complex known as DISC by binding to a Fas-associated adapter protein. A new protein, FLASH, contains a motif with oligomerizing activity whose sequence is similar to that of the Caenorhabditis elegans protein CED-4, and another domain (DRD domain) that interacts with a death-effector domain in caspase-8 or in the adapter protein. FLASH is likely a component of the DISC signalling complex and is necessary for the activation of caspase-8 in Fas-mediated apoptosis.


Synthetic peptide corresponding to residues A(19) S P L K N N D E G S L D(31) of mouse FLASH.
Antigen affinity chromatography
Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
CASP8-associated protein 2, FLICE-associated huge protein, RIP25
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
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