FLIP Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA130801
PA1-30801 detects FLIP from mouse, human, rat samples. PA1-30801 has been successfully used in Western blot applications. The PA1-30801 immunogen is: Peptide corresponding to amino acids 2 to 18 of human FLIP2. The sequence is identical in all FLIP splice variants.FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
|Peptide corresponding to amino acids 2 to 18 of human FLIP2. The sequence is identical in all FLIP splice variants.
|Human, Mouse, Rat
|Immunocytochemistry, Immunofluorescence, Western Blot
|Casper, Inhibitor of FLICE, I-FLICE, FLAME-1,CASH, CLARP, c-FLIP, MRIT, CASH, Usurpin
|117279, 12633, 8837
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