FLIP Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112523
DescriptionFLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
|PBS with 0.02% sodium azide|
|CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLIP, I-FLICE, MRIT, USURPIN, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS|
|-20° C, Avoid Freeze/Thaw Cycles|
|117279, 12633, 8837|
|Synthetic peptide corresponding to residues 2-18 of human FLIP protein.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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