FLT3 Rat anti-Mouse, PE, Clone: 113308, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA523648
In direct ELISAs, no cross-reactivity with recombit human Flt-3 is observed. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
|Mouse myeloma cell line NS0-derived recombit mouse Flt-3/Flk-2 Asn28-Ser544 (predicted)|
|Buffered saline solution with BSA and 0.09% sodium azide|
|FLT3, Fms-like tyrosine kinase 3, receptor-type tyrosine-protein kinase FLT3, CD135, FL cytokine receptor, fetal liver kinase 2, stem cell tyrosine kinase 1|
|4° C, store in dark, DO NOT FREEZE!|
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