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FNIP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520690

Catalog No. PIPA520690


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Description

Description

A suggested positive control is rat skeletal muscle tissue lysate. PA5-20690 can be used with blocking peptide PEP-0805.

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
Specifications

Specifications

FNIP2
Polyclonal
Unconjugated
FNIP2
Liquid
FNIP2
A 16 amino acid peptide near the carboxy terminus of human FNIP2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9P278, Q80TD3
FNIPL, MAPO1; FNIP1-like protein; O6-methylguanine-induced apoptosis 1 protein; folliculin-interacting protein 2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
310538, 329679, 57600
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