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FNTA Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512169

Catalog No. PIPA512169

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine and rat based on sequence homology.

FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence.FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
Specifications

Specifications

FNTA
Polyclonal
PBS with 0.09% sodium azide
P49354, Q61239
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; Ras proteins prenyltransferase alpha; FTase-alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
14272, 2339
Western Blot
Unconjugated
FNTA
Liquid
FNTA
KLH conjugated synthetic peptide between 88-118 amino acids from the central region of human FNTA
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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