FosB Mouse anti-Human, Clone: 83B1138, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141121
Suggested positive control: Hela whole cell extract, HeLa cell lysate.The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates (7,8) and an avian nephroblastoma virus (6). The cellular homolog, c-Fos, encodes a 62 kDa nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers, which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family (4,5). Murine FosB encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements (3). Functional homologs of c-Fos and FosB include Fra-1 and Fra-2 genes (2).
|PBS with 0.05% sodium azide|
|AP-1, DKFZp686C0818, G0S3, GOS3, GOSB, MGC42291|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Synthetic peptide corresponding to residues 2-15 of human FosB.|
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