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FosB Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1831

Catalog No. PA1831

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2.Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

PA1-831 detects FosB from mouse cells and tissues.PA1-831 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~41kDa protein representing FosB and an ~38kDa protein representing FosB2 in NIH 3T3 serum stimulated cells. The PA1-831 immunogen is a synthetic peptide corresponding to residues T(102) S Y S T P G L S A Y S T G G A(117) of mouse FosB.Reconstitute with PBS.
Specifications

Specifications

FosB
Polyclonal
Antibody with no preservative
P13346
FBJ Murine Osteosarcoma Viral Oncogene Homolog-B, G0S3, GOSB
Rabbit
IgG
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
14282
Western Blot
Unconjugated
Fosb
Lyophilized
FOSB
Synthetic peptide corresponding to residues T(102) S Y S T P G L S A Y S T G G A(117) of mouse FosB.
IgG fraction
RUO
Antibody
Polyclonal
Mouse
Documents
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