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FOXP3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512396

Catalog No. PIPA512396


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Description

Description

This antibody is predicted to react with non-human primate based on sequence homology.

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Specifications

Specifications

FOXP3
Polyclonal
PBS with 0.09% sodium azide
Q9BZS1, Q99JB6
Scurfin; Forkhead box protein P3; FOXP3; IPEX;
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
20371, 50943
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
FOXP3
Liquid
FOXP3
KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human FOXP3
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human, Mouse
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