Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Fra2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1832

Catalog No. PA1832

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2.Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.

PA1-832 detects fos-related antigen 2 (Fra2) from human cells.PA1-832 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~58kDa protein representing Fra2 from HeLa cell lysate.The PA1-832 immunogen is a synthetic peptide corresponding to residues L(288) E Q E S P A S P S E S C S K(302) of human Fra2.Reconstitute with PBS.
Specifications

Specifications

Fra2
Polyclonal
Antibody with no preservative
P15408
Fos-Related Antigen-2, FosL2
Rabbit
IgG
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
2355
Western Blot
Unconjugated
FOSL2
Lyophilized
FOSL2
Synthetic peptide corresponding to residues L(288) E Q E S P A S P S E S C S K(302) of human Fra2.
IgG fraction
RUO
Antibody
Polyclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit